PE-22-28 (Spadin) is a synthetic peptide derived from a fragment of the sortilin protein and represents the most active region of spadin. It functions as a potent TREK-1 (two-pore domain potassium channel) inhibitor, with an IC50 value of 0.12 nM, and is widely studied in neuroscience-related research models.

ACDC supplies PE-22-28 5mg as a high-purity lyophilized peptide powder, suitable for controlled laboratory environments. This peptide has been investigated in experimental systems involving neurogenesis, synaptic signaling, and neuronal activity regulation, particularly in studies focused on serotonergic pathways and brain function.

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Product Specifications

Product Name: PE-22-28 (Spadin)
Catalogue Number: PE2228-5mg
Molecular Formula: C35H55N11O9
Molecular Weight: 773.89 g/mol
Purity: ≥95% (HPLC)
CAS Number: 1801959-12-5
Appearance: White lyophilized powder
Form: Lyophilized solid

Research Applications

PE-22-28 has been examined in various laboratory studies related to neuronal signaling and potassium channel activity.

Applications in research include:

• TREK-1 potassium channel inhibition studies
• serotonergic neuron activity research
• hippocampal neurogenesis models
• synaptogenesis and CREB signaling pathways
• investigation of BDNF expression and neuronal plasticity
• cellular studies on neuroprotective mechanisms

In experimental models, PE-22-28 has also been observed in studies related to cell signaling pathways, targeted molecular interactions, and modulation of neuronal communication systems.

Storage and Handling

PE-22-28 from ACDC is supplied as a lyophilized powder for stability during storage and transport.

Recommended storage conditions:

Unopened vial
Store at -20°C

After reconstitution
Store at 2–8°C for short-term use

Avoid repeated freeze–thaw cycles to maintain peptide stability.

For more handling guidance:
https://acdcsource.com/

Synthesis and Quality Control

PE-22-28 is produced using controlled peptide synthesis methods to ensure consistent quality.

Quality assurance includes:

• HPLC purity verification
• molecular identity confirmation
• batch-to-batch consistency testing

Each batch is tested prior to shipment to ensure suitability for laboratory research applications.

Packaging and Shipping

ACDC provides flexible supply options for research and wholesale clients.

Packaging options:

5mg / 10mg / 15mg / 20mg / 30mg per vial
10 vials per kit
custom packaging available

Shipping methods:

DHL
FedEx
UPS
EMS
Air or sea transport for bulk orders

Orders are typically shipped within 3–7 days after confirmation.

About ACDC

ACDC is a supplier of research peptides and intermediates with operations in over 35 countries, serving clients across Europe and the United States. The company focuses on consistent purity, reliable delivery, and scalable supply.

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https://acdcsource.com/

FAQ

Can I get a sample?

Yes. Samples may be available for evaluation. Shipping costs are typically covered by the customer.

What payment methods are accepted?

ACDC accepts bank transfer (T/T), Bitcoin, and other common international payment methods.

What is the minimum order quantity?

Standard MOQ is 1 kg, while smaller research quantities such as 100 g may be arranged with a sample charge.

How long does shipping take?

Orders are generally shipped within 3–7 days, depending on destination and logistics method.

Is PE-22-28 intended for human use?

No. PE-22-28 supplied by ACDC is strictly intended for laboratory research use only and is not approved for human or veterinary use.