Products
KPV 10mg/vial | Inflammation Research Peptide
Product Introduction:
KPV’s core advantage is its potent immune modulation and anti-inflammatory activity. This tripeptide acts on melanocortin receptor-1 (MC1R), blocking the release of pro-inflammatory mediators like TNF-α and IL-6 to curb inflammatory responses. It holds research potential for alleviating skin inflammation (eczema, dermatitis), supporting gut health in inflammatory bowel disease, and modulating autoimmune-related symptoms. Its anti-inflammatory properties also boost skin barrier function and drive tissue repair, making it a valuable tool for inflammation and skin health research.
KPV Peptide (Lys-Pro-Val) | 10mg/Vial – Research-Grade Anti-Inflammatory Tripeptide
Derived from α-MSH C-Terminus | CAS: 337435-44-6 | Made in China
Core Product Specifications
表格
| Parameter | Details |
|---|---|
| Amino Acid Sequence | Lys-Pro-Val (KPV) |
| CAS Number | 337435-44-6 |
| Molecular Formula | C₁₅H₂₇N₄O₃ |
| Molecular Weight | 311.40 g/mol |
| Purity | ≥98.0% (HPLC Verified) |
| Appearance | White lyophilized powder |
| Storage (Unreconstituted) | -20°C, frozen, protected from light (24-month shelf life) |
| Storage (Reconstituted) | 2–8°C refrigeration; avoid repeated freeze-thaw cycles |
Core Advantages & Research Applications
KPV is a bioactive tripeptide fragment corresponding to the C-terminus of α-melanocyte-stimulating hormone (α-MSH)—the key sequence responsible for α-MSH’s anti-inflammatory and tissue-protective activity. This small-molecule peptide binds selectively to melanocortin receptor 1 (MC1R), regulating the NF-κB pathway and blocking the release of pro-inflammatory mediators.
Its high efficiency, low molecular weight, and exceptional stability make it a staple research tool for studies involving:
- Inflammatory bowel disease (IBD) and mucosal repair
- Cutaneous inflammation (dermatitis, eczema) and skin barrier function
- Autoimmune disorder mechanisms
- Tissue repair and regenerative medicine
- Anti-inflammatory drug discovery and development
Key Mechanisms of Action
- MC1R Targeting: High-affinity binding to melanocortin receptor 1 triggers downstream anti-inflammatory signaling cascades.
- NF-κB Inhibition: Directly suppresses pathway activation, reducing production of pro-inflammatory cytokines (e.g., TNF-α, IL-6).
- Immune Modulation: Shapes T-cell differentiation and macrophage polarization to foster an anti-inflammatory microenvironment.
- Antioxidant Activity: Scavenges reactive oxygen species (ROS), mitigating oxidative stress damage in target tissues.
- Mucosal Repair: Promotes intestinal epithelial cell integrity and barrier restoration in inflamed tissues.
- Tissue Selectivity: Accumulates preferentially at sites of inflammation (intestine, skin) for localized action.
Manufacturing & Quality Assurance (China-Made Excellence)
Our KPV peptide is produced using Fmoc solid-phase synthesis (≥85% yield) and purified via a two-step process (ion exchange chromatography + reversed-phase HPLC) to ensure exceptional batch consistency.
Rigorous Quality Control Standards
- Purity: Main peak ≥98.0%; single impurities ≤0.5%
- Chirality: L-amino acid configuration; optical purity ≥99.5%
- Structural Confirmation: Mass spectrometry (MS) + nuclear magnetic resonance (NMR) verification
- Content: Amino acid analysis confirms ≥95.0% peptide content
- Moisture: ≤5.0% (Karl Fischer titration)
- Endotoxin: <10 EU/mg (meets research-grade requirements)
Functional Activity Validation
Every batch undergoes pre-shipment activity testing to ensure biological relevance:
- In Vitro Anti-Inflammatory Assay: Inhibition of LPS-induced TNF-α release in cellular models
- Permeability Testing: Caco-2 cell model validation for intestinal mucosal absorption
- Stability Studies: Evaluated for solution stability, photostability, and temperature tolerance
Product Key Features
- Gastrointestinal Stability: Resilient in GI environments—ideal for oral administration research
- Superior Permeability: Excellent mucosal penetration, suited for local drug delivery studies
- Inflammation Targeting: Selective accumulation at inflamed sites reduces off-target effects
- Endogenous Safety Profile: Derived from human α-MSH, offering outstanding biocompatibility for preclinical research
Reconstitution, Usage & Storage Guidelines
1. Reconstitution Protocols (10mg Vial）
| Application | Recommended Solvent | Standard Preparation |
|---|---|---|
| General Research | Sterile PBS (pH 7.4) | 1mL PBS → 10mg/mL (32mM) stock solution |
| Cell Culture | Sterile DMSO (final <0.1%) or culture medium | Dilute stock to working concentration post-dissolution |
| In Vivo Studies | 0.9% Saline (or saline + 0.1% BSA) | Adjust volume for desired dosing concentration |
Critical Handling Notes:
- Gently vortex to dissolve—avoid vigorous shaking (prevents peptide denaturation)
- Prepare fresh for immediate use whenever possible
- Aliquot stock solutions to eliminate repeated freeze-thaw cycles
- Use aseptic technique to prevent contamination
2. Recommended Working Concentrations
- Cell experiments: 1–100 μM
- In vivo studies: 0.1–5 mg/kg
- Receptor binding assays: 0.1–10 μM
3. Storage & Transportation
- Lyophilized Powder: -20°C, dry, light-protected (24 months)
- Reconstituted Solution: 4°C for up to 7 days; -20°C for up to 1 month (aliquoted)
- Transport: Room temperature (≤25°C) for up to 7 days; ice pack recommended for long-haul shipments (avoids high heat/humidity)
Why Choose Our China-Made KPV Peptide?
- Established Synthesis Expertise: Mature Fmoc solid-phase process with years of peptide manufacturing experience
- Stringent Quality Control: Comprehensive testing (MS/NMR/HPLC) and functional activity validation
- Consistent Batch Performance: Tight tolerance ranges for purity, endotoxin, and activity
- Research-Focused Support: Technical guidance for reconstitution, dosing, and experimental design
Final Note
KPV is a highly potent, low-molecular-weight anti-inflammatory tripeptide, invaluable for advancing research in inflammatory diseases and tissue repair. Our China-based manufacturing combines cutting-edge synthesis technology with rigorous quality assurance to deliver a reliable, biologically active research tool—supporting your drug discovery and mechanistic research efforts.
For custom synthesis, bulk pricing, or technical inquiries, contact our team directly.
| Contact Channel | Contact Information | |
| +852 54965382 | ||
| Telegram | @Acdcsours | |
| Gmail | allenraws0437@gmail.com |
